July 21, 2011

Mutual Antagonism of T Cells Causing Psoriasis and Atopic Eczema

Stefanie Eyerich, Ph.D., Anna T. Onken, M.D., Stephan Weidinger, M.D., Andre Franke, M.D., Francesca Nasorri, Ph.D., Davide Pennino, Martine Grosber, M.D., Florian Pfab, M.D., Carsten B. Schmidt-Weber, Ph.D., Martin Mempel, M.D., Ruediger Hein, M.D., Johannes Ring, M.D., Ph.D., et al.

First published: 21 July 2011


The simultaneous occurrence of psoriasis driven by type 1 helper T (Th1) cells and type 17 helper T (Th17) cells and atopic eczema dominated by type 2 helper T (Th2) cells is rare. Here, we describe three patients with co-occurring psoriasis and atopic eczema with an antagonistic course and distinct T-cell infiltrates in lesions from psoriasis and those from atopic eczema. Sensitized patients with psoriasis had a reaction to epicutaneous allergen challenge, with clinically and histologically verified eczema lesions containing a large number of allergen-reactive T cells. These findings support a causative role for T cells triggered by specific antigens in both psoriasis and atopic eczema.