Stefanie Eyerich, Ph.D., Anna T. Onken, M.D., Stephan Weidinger, M.D., Andre Franke, M.D., Francesca Nasorri, Ph.D., Davide Pennino, Martine Grosber, M.D., Florian Pfab, M.D., Carsten B. Schmidt-Weber, Ph.D., Martin Mempel, M.D., Ruediger Hein, M.D., Johannes Ring, M.D., Ph.D., et al.
First published: 21 July 2011
Summary
The simultaneous occurrence of psoriasis driven by type 1 helper T (Th1) cells and type 17 helper T (Th17) cells and atopic eczema dominated by type 2 helper T (Th2) cells is rare. Here, we describe three patients with co-occurring psoriasis and atopic eczema with an antagonistic course and distinct T-cell infiltrates in lesions from psoriasis and those from atopic eczema. Sensitized patients with psoriasis had a reaction to epicutaneous allergen challenge, with clinically and histologically verified eczema lesions containing a large number of allergen-reactive T cells. These findings support a causative role for T cells triggered by specific antigens in both psoriasis and atopic eczema.